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Quantum Nuova is a cutting-edge single-cell Nano-MRI platform designed for biomedical research. It enables precise investigation of oxidative stress and its impact on various health conditions with nanomolar level sensitivity and sub-cellular resolution.
Quantum Nuova uses NV center diamond magnetometry technology combined with a confocal microscope to detect and measure free radicals at the nanomolar level with sub-cellular resolution, allowing researchers to monitor cell responses to oxidative stress in real-time.
Quantum Nuova has been successfully applied in research related to antibiotics, immune response, arthritis, male fertility, and cancer. It allows researchers to observe stress reactions of individual organelles and assess cell viability with nanoscale resolution.
Yes, Quantum Nuova can work with both live and fixed samples, allowing for non-invasive measurements at the cellular level. This versatility makes it valuable for a wide range of biomedical research applications.
Quantum Nuova's unique combination of quantum sensing with diamond magnetometry provides unprecedented nanoscale resolution for measuring cellular stress responses. This allows researchers to observe reactions within individual organelles that other technologies cannot detect.
You can book a demo through the website to experience Quantum Nuova firsthand. The product is available for purchase with options for base units, optional accessories, and consumables. For more information, you can contact QT Sense directly at [email protected] or visit their facility in Groningen, Netherlands.
Research & Development
Nitrogen vacancy (NV) centers are nitrogen atoms and an adjacent vacancy, which replace carbon atoms in diamonds. Diamonds with such defects are called fluorescent nanodiamonds (FNDs). The NV centers can be exploited to perform quantum measurements. The fluorescence from excited NV centers can be measured to detect surrounding magnetic field resonances (magnetic noise) with high sensitivity and spatial resolution.
This approach is valuable because it allows for localized, non-invasive measurements of free radicals within living cells without the need for external markers or dyes, which can affect cell viability or introduce measurement biases. T1 relaxometry's ability to detect free radicals down to nanomolar concentrations and its application across various biological contexts (e.g., drug delivery, research) underscores its potential to advance our understanding of cellular dynamics and disease mechanisms.
Using quantum sensing in the form of diamond magnetometry allows you to take measurements of extremely sensitive nanoscale magnetic noise, otherwise near impossible to detect. Analogously to T1 measurements in conventional magnetic resonance imaging (MRI), relaxometry allows the detection of different concentrations of paramagnetic species. In this way you can recreate an MRI with subcellular resolution.
The confocal microscope is primarily used to localize the functionalized nanodiamonds that have been injected into the cell for quantum sensing. Once the location is known, the nanodiamonds can be pumped into an excited state by the laser to be used for quantum sensing. It can also be used to image the cells.
The Quantum Nuova is fully enclosed so the user has no interaction with the laser light, inner electronics, or alignment. Furthermore, a cell incubator can be attached for samples requiring specific conditions. The instrument is safe to use in an environment adhering to standard laboratory rules.
Interested in receiving information or specifics about relaxometry?
This allows for the observation of relaxation times that are affected by the cell’s internal conditions.
