Deeptech behind free radical measurements
Quantum Nuova delivers stabilized quantum magnetometry for real-time, nanometer-resolution detection of free radical kinetics inside living biological systems.
Engineered for quantum precision. Built for biological complexity.
Quantum Nuova detects free radicals in live cells using NV-based magnetometry, delivering subcellular sensitivity through integrated optics, stabilized architecture, and uncompromising signal precision.
Precision optics. No optical bench required
Quantum Nuova integrates a stabilized confocal optical system requiring no dark room, optical bench, or vibration-isolated setup. Housed in a compact enclosure, it captures diffraction-limited images and quantum signals with micron-level alignment—ready for any standard lab without infrastructure upgrades.
Engineered optical architecture
At the heart of Quantum Nuova lies a precision-tuned confocal system: a 561 nm pulsed laser, 100× NA 1.30 oil objective, galvo scanning, and sub-200 nm resolution. Internally mounted optics and spatial filtering ensure stable excitation and fluorescence capture during extended imaging sessions.
Single-Photon magnetic noise detection
Quantum Nuova detects radical-induced magnetic noise using T1 curves and NV-center quantum sensors. A SPAD-based detector captures single photons through an optically shielded path. With nanomolar sensitivity, the system requires no cryogenics or coils—just engineered light, precision timing, and quantum fidelity.
Software calibrated accuracy and control
Quantum Pulse 1.0 controls every experimental parameter—laser pulses, T₁ scan sequences, Z-stage positioning, and image capture. It automates mosaic scans, T₁ fitting, and particle relocation, archiving all metadata. Researchers gain full-stack digital control for repeatable, high-precision quantum sensing workflows.
Stability, portability and integration
Engineered for real-world labs, Quantum Nuova runs on standard power with air cooling. It fits on a benchtop, maintains alignment via auto-calibration, and operates from 10–35 °C. No vibration table. No blackout room. Just precision magnetometry—miniaturized, stable, and ready out-of-the-box.
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Discover how NV-based magnetometry reveals hidden free radical kinetics with quantum-enabled precision. From metabolism to disease, uncover insights invisible to conventional methods.
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Clinical applications
Quantum Nuova opens new possibilities for clinical and translational science by enabling real-time, subcellular detection of oxidative stress, a key driver across many diseases. By capturing functional free radical activity at the single-cell level, it supports biomarker discovery, patient stratification, and therapy response prediction in several critical fields:
Monitor cellular stress linked to neuronal and glial cell damage through free radical biomarkers
Common questions
Research & Development
Nitrogen vacancy (NV) centers are nitrogen atoms and an adjacent vacancy, which replace carbon atoms in diamonds. Diamonds with such defects are called fluorescent nanodiamonds (FNDs). The NV centers can be exploited to perform quantum measurements. The fluorescence from excited NV centers can be measured to detect surrounding magnetic field resonances (magnetic noise) with high sensitivity and spatial resolution.
This approach is valuable because it allows for localized, non-invasive measurements of free radicals within living cells without the need for external markers or dyes, which can affect cell viability or introduce measurement biases. T1 relaxometry's ability to detect free radicals down to nanomolar concentrations and its application across various biological contexts (e.g., drug delivery, research) underscores its potential to advance our understanding of cellular dynamics and disease mechanisms.
Using quantum sensing in the form of diamond magnetometry allows you to take measurements of extremely sensitive nanoscale magnetic noise, otherwise near impossible to detect. Analogously to T1 measurements in conventional magnetic resonance imaging (MRI), relaxometry allows the detection of different concentrations of paramagnetic species. In this way you can recreate an MRI with subcellular resolution.
The confocal microscope is primarily used to localize the functionalized nanodiamonds that have been injected into the cell for quantum sensing. Once the location is known, the nanodiamonds can be pumped into an excited state by the laser to be used for quantum sensing. It can also be used to image the cells.
The Quantum Nuova is fully enclosed so the user has no interaction with the laser light, inner electronics, or alignment. Furthermore, a cell incubator can be attached for samples requiring specific conditions. The instrument is safe to use in an environment adhering to standard laboratory rules.
