Bring free radical precision to the discovery pipeline
Move beyond indirect markers. Gain precise biomarkers and dynamic, real-time data to accelerate the discovery process.
Quantum Nuova™ delivers precise biomarkers and high-resolution free radical data, unlocking new possibilities for mechanistic insight and discovery.
In vitro high resolution measurements
Unprecedented Single-cell & subcellular resolution. Move beyond population averages to resolve cellular heterogeneity. Quantum Nuova precisely maps free radical activity down to 300nm within individual cells and organelles, providing granular insights critical for understanding disease pathogenesis and treatment response.
Real-time insights
Unlike static dye-based methods, Quantum Nuova delivers dynamic, continuous measurements. Track the generation, depletion, and interplay of free radicals as they happen in living cells, revealing transient signaling events, drug effects, and time-dependent processes.
Sophisticated data analysis
Turn complex data into clear biological insights. Our advanced data analysis software helps you process real-time free radical monitoring and oxidative stress detection data to quickly identify key free radical insights.
Detect free radicals in the nanomolar range
Detect even minute fluctuations in free radical concentrations. Quantum Nuova offers unmatched sensitivity, allowing you to quantify elusive free radicals at nanomolar levels for highly accurate and quantitative insights.
Elevate science discovery with quantum precision
Gain new and clear insights into oxidative stress and free radical biology right at the single-cell level. Helping research more precisely by measuring free radicals directly and in real time.
Principle of operation
Our system leverages advanced Fluorescent Nanodiamond sensors (FNDs), powered by NV center biosensing, functioning as exquisite quantum biosensors for biology. These tiny sensors are uniquely sensitive, precisely detecting the dynamic presence of free radical biomarkers and the intricate shifts in cellular oxidative stress right at the nano-scale level. By optically reading the quantum state of these sensors, Quantum Nuova delivers true real-time free-radical monitoring.
The right solution for your research
Quantum Nuova - Discovery
Engineered for precise T1 curves. Reliable, high-performance systems for any research setup.
Optical and Imaging Properties
- Green Laser Source – 561 nm (50 mW)
- 100× Oil Immersion Objective (NA 1.30)
- 260 nm Nominal Resolution / 170 nm Lateral Resolution
- Z-Stack Resolution: 25 nm
- 605 nm Emission Lowpass Filter
- Bright Field FOV: 200 × 200 µm
- Galvomirror for Lateral Scanning
- Frame Rate: Up to 1 f/s (higher for cropped regions)
Magnetometry Specifications
- T1 Relaxometry Measurement
- Scan Time: < 1 minute
- Nanomolar-scale Radical Detection
- Single Photon APD Detector
- Longpass Filter Set: 650 nm, 700 nm, 750 nm
- Motorised Detection Filter System
Device Layout
- Compact Design: 80 × 80 × 30 cm (35 kg)
- Operating Voltage: 100–240 VAC, 50/60 Hz
- Air-Cooled Operation
- Environment Range: 10 °C to 35 °C, <90% R.H.
- Control Box: 40 × 40 × 30 cm
Common questions
Research & Development
Nitrogen vacancy (NV) centers are nitrogen atoms and an adjacent vacancy, which replace carbon atoms in diamonds. Diamonds with such defects are called fluorescent nanodiamonds (FNDs). The NV centers can be exploited to perform quantum measurements. The fluorescence from excited NV centers can be measured to detect surrounding magnetic field resonances (magnetic noise) with high sensitivity and spatial resolution.
This approach is valuable because it allows for localized, non-invasive measurements of free radicals within living cells without the need for external markers or dyes, which can affect cell viability or introduce measurement biases. T1 relaxometry's ability to detect free radicals down to nanomolar concentrations and its application across various biological contexts (e.g., drug delivery, research) underscores its potential to advance our understanding of cellular dynamics and disease mechanisms.
Using quantum sensing in the form of diamond magnetometry allows you to take measurements of extremely sensitive nanoscale magnetic noise, otherwise near impossible to detect. Analogously to T1 measurements in conventional magnetic resonance imaging (MRI), relaxometry allows the detection of different concentrations of paramagnetic species. In this way you can recreate an MRI with subcellular resolution.
The confocal microscope is primarily used to localize the functionalized nanodiamonds that have been injected into the cell for quantum sensing. Once the location is known, the nanodiamonds can be pumped into an excited state by the laser to be used for quantum sensing. It can also be used to image the cells.
The Quantum Nuova is fully enclosed so the user has no interaction with the laser light, inner electronics, or alignment. Furthermore, a cell incubator can be attached for samples requiring specific conditions. The instrument is safe to use in an environment adhering to standard laboratory rules.
