Fluorescent nanodiamond for sperm cell viability

Fluorescent nanodiamond labels: Size and concentration matters for sperm cell viability

Today Bio (2023)

The study explores the potential of fluorescent nanodiamonds (FNDs) in biomedical applications, specifically focusing on their biocompatibility with sperm cells for applications in studying infertility and labeling sperm cells. The research assesses various sizes and concentrations of nanodiamonds, examining their impact on sperm cell metabolic activity, membrane integrity, morphology, and reactive oxygen species formation in both uncapacitated and capacitated states. It concludes that FNDs' biocompatibility varies, with larger particles and lower concentrations being better tolerated, especially in the capacitated state of cells, indicating the need for careful consideration in biomedical applications​