Unlocking Huntington's Disease with Diamond Quantum Sensing

Diamond Quantum Sensing Revealing the Relation between Free Radicals and Huntington’s Disease

ACS Central Science (2023)

This technique, which utilizes fluorescent nanodiamonds (FNDs) capable of detecting magnetic changes caused by free radicals, enables nanoscale MRI measurements with subcellular resolution. The research focused on whether radical generation occurs near PolyQ aggregates in human embryonic kidney cells expressing Huntington's disease markers. Findings revealed that nanodiamonds are highly colocalized with PolyQ aggregates at autolysosomes, and an increase in PolyQ aggregation was correlated with heightened production of free radicals, suggesting a link between PolyQ aggregation, autolysosome dysfunction, and free radical production.