Quantum Sensing of Viral Infections

Applying NV center-based quantum sensing to study intracellular free radical response upon viral infections

Redox Biology (2022)

By employing optical probing and measuring the spin-lattice relaxation (T1) of NV defect ensembles in intracellular nanodiamonds, the research pinpoints alterations in free radical levels near infectious viruses. This innovative approach allows for precise measurement of free radical concentration changes at random cellular locations and specifically near virus entry points, providing insights into intracellular dynamics during viral replication. Additionally, the study utilizes relaxometry to monitor free radical variations in real-time during the early stages of infection, offering a novel method to understand virus pathogenesis and aiding in the development of effective antiviral drugs or vaccines.