Applications
Discover the most recent research and publications on quantum sensing
Fluorescent Nanodiamonds for Tracking Single Polymer Particles in Cells and Tissues
Fluorescent Nanodiamonds for Tracking Single Polymer Particles in Cells and Tissues
This article presents a novel method for the long-term imaging and tracking of polymer nanoparticles within biological systems using fluorescent nanodiamonds (FNDs). Unlike conventional fluorescent dyes, FNDs do not bleach or blink, enabling continuous tracking in cells and liver tissues. The study demonstrates how FNDs, embedded within polymer nanoparticles, can be used to visualize and understand the transport routes of these particles in cellular and tissue environments, highlighting FNDs' potential for biomedical imaging and environmental studies on nanoparticle behavior.
Analytical Chemistry (2023)
Optimizing Data Processing
Optimizing Data Processing for Nanodiamond Based Relaxometry
This article compares different methods for analyzing T1 data in nanodiamonds using nitrogen-vacancy centers. It evaluates single, biexponential, and stretched exponential models for fitting T1 curves. The study introduces techniques like pulse fitting and bootstrap to reduce noise and presents a rolling window method to analyze temporal evolution. By examining various gadolinium concentrations in chemical samples, it finds that stretched and biexponential fits better differentiate concentrations, particularly at higher levels. This research provides insights into optimizing data processing in quantum sensing applications.
Adv Quantum Technol. (2023)
T1 Relaxometry
Relaxometry with Nitrogen Vacancy (NV) Centers in Diamond
Relaxometry, using diamonds with Nitrogen-Vacancy (NV) centers, is a precise method for measuring tiny magnetic changes at the nanoscale. In this process, NV centers in diamonds—defects where nitrogen replaces carbon—are aligned by a laser pulse and emit fluorescent light upon returning to their normal state. This technique, crucial in detecting magnetic fields influenced by their surroundings, is especially valuable in biological research for identifying and analyzing free radicals within cells, offering significant insights into complex biological processes and diseases.
Accounts of Chemical Research (2022)
Future Directions
Intracellular Relaxometry, Challenges, and Future Directions
Relaxometry with Nitrogen-Vacancy (NV) centers in diamonds, a technique where laser-stimulated NV centers emit light to measure magnetic fields, is advancing biological research by allowing detailed study of subcellular structures. The technique faces challenges in consistency and biocompatibility. Future directions include using larger NV center ensembles and exploring new materials proposed to enhance analysis and understanding of cellular processes and diseases.
ACS Central Science (2022)
Nanodiamond Detection in Biological Conditions
Nanodiamond Relaxometry-Based Detection of Free-Radical Species When Produced in Chemical Reactions in Biologically Relevant Conditions
Diamond magnetometry, employing nanodiamonds with nitrogen vacancy centers, offers nanoscale detection similar to T1 MRI relaxation. This method, effective in real-time free radical monitoring in chemical reactions, distinguishes spin noise from different species. It demonstrates high sensitivity within biological environments, achieving nanomolar detection limits, and marks progress towards label-free nano-MRI quantification in biological settings.
ACS Sensors (2020)
How to get nanodiamond into cells?
Effect of medium and aggregation on antibacterial activity of nanodiamonds
Fluorescent nanodiamonds, used in diverse applications, display varying biocompatibility with bacteria, unlike their known compatibility in mammalian cells. This article reviews and experiments with different bacterial strains, nanoparticle sizes, and chemistries, revealing that particle aggregation and bacterial clumping can erroneously suggest bactericidal effects. The study concludes that these aggregations and the bacteriostatic effects of nanodiamond attachment are key factors in the observed results, rather than any specific material property of the nanodiamonds.
Materials science & engineering c-Biomimetic and supramolecular systems (2020)
Quantum Monitoring in Mitochondria
Quantum monitoring of cellular metabolic activities in single mitochondria
The study highlights the use of relaxometry in diamond magnetometry for precise detection of free radicals in cells, specifically targeting mitochondria within macrophages. The research showcases the versatility of functional nanodiamonds in biomedical applications due to their biocompatibility and unique ability to convert magnetic to optical signals, marking a significant advancement in understanding cellular processes at the nanoscale.
Science Advances (2021)
Review on Nanodiamonds in Cells
Nanodiamonds and Their Applications in Cells
Explore the use of nanodiamonds in cellular applications, highlighting their unique properties such as stability and biocompatibility, which make them suitable for drug delivery, biological labeling, and quantum sensing. Nanodiamonds can be ingested by cells, with their biocompatibility and cytotoxic effects varying across cell lines.
Small (2018)
Review on Nanodiamonds in Organisms
Nanodiamonds for In Vivo Applications
Delve into the multifaceted applications of nanodiamonds (NDs), including their use in drug delivery, cancer therapy, and biomedical implants. These tiny diamonds are prized for their unique optical properties and quantum sensing capabilities, making them ideal for delivering drugs and genetic materials directly to target areas, thereby enhancing treatment efficacy while minimizing side effects. Notably, their application extends to improving the mechanical properties of composites in medical implants, like promoting bone formation, due to their hardness and customizable surface.